//m.lakotalakes.com/jprr Heighpubs开放获金博宝app体育取期刊上 en - us 08/09/2021//m.lakotalakes.com/jprr/jprr-aid1030.php & lt; h2> Abstract< / h2><p>Introduction - evolution of SARS-CoV-2 variants: With the unrestrained pandemic for over last one-and-half year, SARS-CoV-2 seems to have adapted to its habitat, the human host, through mutations that facilitate its replication and transmission. The G variant incorporating D614G mutation, potently more transmissible than the ancestral virus arose during January 2020 and spread widely. Since then, various SARS-CoV-2 variants of concern (VOCs) and variants of interest (VOIs) with higher infectivity or virulence or both, have evolved on the background of G variant, and spread widely.</p> <p>SARS-CoV-2 infection and the immunodynamics: As the virus becomes more transmissible, its lethality may drop. Apart from the humoral immunity, T-cell recognition from a previous SARS-CoV-2 infection or vaccination may modify the disease transmission correlates and its clinical manifestations. On the other hand, the immunity generated may reduce probability of re-infection as well as limit evolution of adaptive mutations, and emergence of highly infectious and immune-escape variants. There are complex issues related to the SARS-CoV-2 evolutionary dynamics and host&rsquo;s immunodynamics.</p> <p>Trending etiopathoimmunological correlates: The evolution potential of SARS-CoV-2 is limited because of proofreading function of nsp14. The S protein mutations affect transmissibility, virulence, and vaccine efficacy. The D614G mutation in G variant with higher infectivity has turned the Chinese epidemic into a pandemic. Other SARS-CoV-2 variants, such as Alpha, Beta, Gamma, and Delta seem to have evolved as result of adaptation to selective pressures during periods of prolonged infections and subsequent transmission. Further, there is issue of convergent association of mutations.</p> <p>Basics of immunity and immune system failure: The nature of the immune response after natural SARS-CoV-2 infection is variable and diverse. There are pre-existing neutralizing antibodies and sensitized T cells elicited during previous infection with seasonal CoVs influencing the disease susceptibility and course. The virus has evolved adaptive mechanisms to reduce its exposure to IFN-I and there are issues related to erratic and overactive immune response. The altered neutralizing epitopes in the S protein in SARS-CoV-2 variants modify the immune landscapes and clinical manifestations.</p> <p>Conclusion: current scenarios and prospects: Presently, the SARS-CoV-2 infection is widespread with multiple evolving infectious variants. There is probability of its transition from epidemic to endemic phase in due course manifesting as a mild disease especially in the younger population. Conversely, the pandemic may continue with enhanced disease severity due to evolving variants, expanded infection pool, and changing immunity landscape. There is need to plan for the transition and continued circulation of the virus during the endemic phase or continuing pandemic for indefinite period.</p> 08/05/2021//m.lakotalakes.com/jprr/jprr-aid1029.php <p>Pulmonary Alveolar Proteinosis (PAP) is a rare lung disease characterized by excessive accumulation of surfactant lipids and proteins in alveoli and terminal airways. It is caused by impaired GM-CSF signaling [1]</p> 08/04/2021//m.lakotalakes.com/jprr/jprr-aid1028.php & lt; p>一个57岁的女人已经被我们医院在2020年4月,因为苦难坏死性肺炎右上肺叶继发于肺动脉栓塞前一年前的一半(图1 A、B)。; / p> 08/04/2021//m.lakotalakes.com/jprr/jprr-aid1027.php & lt; h2> Abstract< / h2>& lt; p>尽管,肺癌是吸烟男性老年人当中更为普遍,但是它也可能发展年轻女性不吸烟的记忆之一。我们在这里报告的历史一个不吸烟的女人,40岁,在第四阶段肺腺癌的诊断。尽管事实上,女人收到三行姑息性化疗,疾病进展。后肿瘤的样品测试通过遗传方法,ROS1突变检测,病人接受ROS1抑制剂,Crizotinib。大幅改善,观察已经经过第一周的治疗。月腺癌收缩后,和具体的锁骨上淋巴结消失了。不幸的是,由于融资问题是停止治疗,该病之后开始迅速进展,病人去世一个月后由于脑转移。这种情况下也值得注意,因为病人首次诊断与血栓出现在小腿深静脉血栓形成倾向,左心室心脏和肺腺癌中发现偶尔当胸腔镜手术活检标本来自可疑右肺下叶的质量。这个故事提醒我们,肺癌可能开始一个副肿瘤综合征,如血栓形成倾向在这种情况下,发现肺腺癌的年轻,不吸烟的人表明可能ROS1基因突变。 In such cases early treatment with ROS1 protein-tyrosine kinase inhibitors should be started as soon as possible.</p> 07/30/2021//m.lakotalakes.com/jprr/jprr-aid1026.php & lt; h2> Abstract< / h2>& lt; p>肺毛霉菌病是一个罕见的肺真菌病、免疫功能不全的常见的个人。它是由真菌引起的类接合菌纲。这是第三个最常见的曲霉病后侵入性真菌感染、念珠菌病。风险因素包括血液恶性肿瘤患者,糖尿病,免疫力低下的状态。很难诊断早期由于非特异性临床表现和延迟治疗相关死亡率更高。我们知道,结核病和艾滋病在像印度这样的国家非常普遍。肺结核后正成为肺毛霉菌病的危险因素在印度这样的发展中国家。non-resolving肺炎患者通常被误诊为肺结核。肺毛霉菌病的诊断是根据临床标本真菌菌丝的示范。 We highlight the importance of clinical suspicion in these cases for early diagnosis and early treatment initiation can reverse morbidity and mortality associated with Pulmonary Mucormycosis. We report 2 cases of Pulmonary mucormycosis present in post-pulmonary tuberculosis patients.</p> 07/30/2021//m.lakotalakes.com/jprr/jprr-aid1025.php & lt; h2> Abstract< / h2>& lt; p>我们知道,哮喘和慢性阻塞性肺疾病为特征的疾病,他们可以共存asthma-COPD重叠(ACO)。asthma-chronic共处的阻塞性肺疾病重叠(ACO)在慢性阻塞性肺疾病(COPD)患者常常是无法识别的。患者初步诊断慢性阻塞性肺病或哮喘,识别算法有更好的预后和治疗。这类病人经历频繁发作,生活质量差,快速的肺功能下降和高死亡率比COPD和哮喘。吸入的类固醇提供这类患者显著减轻症状和一些研究表明,最严重的患者可能对生物制剂表示严重的哮喘。哮喘和慢性阻塞性肺病病人组件常常存在严重缺氧,因为不可逆转/固定气道阻塞和损伤肺泡扩散能力的气性变化。相反,慢性阻塞性肺病患者有哮喘组件不仅有劳力性呼吸困难,而且开发夜间阵发性呼吸困难或呼吸困难或清晨。标准诊断asthma-COPD重叠(ACO)包括积极的支气管扩张剂反应,或先前诊断哮喘痰嗜酸细胞增多症,高IgE和/或异位性的历史。有缺乏文献在像印度这样的国家。 We highlight the importance of identification of Asthma COPD overlap as different phenotype from COPD or asthma alone as it is challenging to diagnose ACO in India. We report 3 cases having both the features of asthma and COPD, later diagnosed with Asthma-COPD overlap.</p> 06/25/2021//m.lakotalakes.com/jprr/jprr-aid1024.php & lt; h2> Abstract< / h2>& lt; p>组织肺炎(OP),可以看到与肺损伤、感染、药物中毒,结缔组织疾病。类风湿性关节炎(RA)病人容易发展间质性肺病(ILD),但肺参与通常发生几年后共同表现。只在10%左右RA的情况下,疾病的最初表现可以在间质性肺病的形式。OP作为初始类风湿性关节炎的表现极其罕见。;/ p>& lt; p>这里提出的52岁男性面对OP RA的最初表现。调查,RA因子和anti-CCP抗体阳性。基于临床、放射学和组织病理学结果诊断成立。;/ p> 06/18/2021//m.lakotalakes.com/jprr/jprr-aid1023.php & lt; h2> Abstract< / h2>& lt; p>囊性纤维化解释本文表明应对疾病的消除污染的最重要来源。你们;/ p> 06/15/2021//m.lakotalakes.com/jprr/jprr-aid1022.php & lt; h2> Abstract< / h2>& lt; p>简介:常年大流行:SARS-CoV-2病毒带来的严峻挑战和COVID-19疾病。与大流行的持久性就一年半,它正在担心COVID-19可能成为新的现实世界与人类生存,人类可能不得不忍受这几年甚至几十年。此外,疾病进一步发展的严重性质与病毒基因组变化的突变和变异的进化形式,可能与增强的传染性和毒性。;/ p>& lt; p>急性和慢性阶段COVID-19:流行病学,越来越清楚的是,除了先进的年龄和预先存在的条件,如糖尿病、心血管、肺和肾脏疾病,某些成分因素使一些病人更容易更严重形式的疾病。这些因素影响COVID-19表现,,,后来康复期以及新定义的,而长COVID阶段。感染的实质性的决议后持续发病率表明坚持多系统的影响,而长Covid&,灵活;/ p>& lt; p>肺损伤与COVID-19: COVID-19主要是呼吸系统疾病有广泛的呼吸道参与从轻微的上呼吸道苦难进步致命的病毒性肺炎和呼吸衰竭。它会影响呼吸系统以不同的方式在疾病严重度的谱,根据年龄、免疫状态和并发症。症状可能轻微,如咳嗽、气短和发烧,严重和重要疾病,包括呼吸衰竭、休克、细胞因子危机,和多器官衰竭。;/ p> <p>Implications for the post-COVID care: Depending on the severity of respiratory inflammation and damage, as well as associated comorbidities, duration of injury and genetics, the progressive fibrosis leads to constriction and compression of lung tissues and damage to pulmonary microvasculature. Consequently, the COVID-19 patients with moderate/severe symptoms are likely to have a significant degree of long-term reduction in lung function. Depending on the severity of the disease, extensive and long-lasting damage to the lungs can occur, which may persist after resolution of the infection.</p> <p>Managing the long COVID&rsquo;s challenges: Given global scale of the pandemic, the healthcare needs for patients with sequelae of COVID-19, especially in those with lung affliction are bound to increase in the near future. The challenge can be tackled by harnessing the existing healthcare infrastructure, development of scalable healthcare models and integration across various disciplines with a combination of pharmacological and non-pharmacological modalities. Following clinical and investigational assessment, the therapeutic strategy should depend on the disease manifestations, extent of damage in lungs and other organs, and associated complications.</p> 03/24/2021//m.lakotalakes.com/jprr/jprr-aid1021.php & lt; h2> Abstract< / h2><p>Meigs syndrome is an uncommon presentation, where a benign ovarian neoplasia presents along with ascites and pleural effusion. About 1% of ovarian neoplasia can present as Meigs syndrome. Patients with Meigs&rsquo; syndrome and elevated serum CA-125 are not frequently reported. We report a case of a 50-year-old women who presented with shortness of breath, cough, weight loss of one and half month duration. Chest radiograph of the patient with clinical examination of patient confirms pleural effusion as cause of progressive shortness of breath. The presence of a pelvic mass and elevated serum CA-125, which raised the possibility of malignancy. After complete resection of tumor, the pathologic reports confirmed a benign ovarian neoplasia. We highlight the importance of suspicion, careful general examination, radiological assessment and histological tests to confirm the diagnosis of Meigs&rsquo; syndrome.</p> 02/26/2021//m.lakotalakes.com/jprr/jprr-aid1020.php & lt; h2> Abstract< / h2><p>Chronic fatigue syndrome (CFS) is a poorly-understood respiratory condition that affects millions of individuals. Hyperbaric oxygen therapy (HBOT) is a treatment option being considered to address CFS as it is suggested to combat fatigue and increase oxygenation. HBOT provides two opportunities in advancing research of CFS: it may provide data on symptom amelioration and be utilized in the search for a biomarker. By either identifying biomarkers before using HBOT to compare epigenomes of patients before and after treatment or using HBOT to find epigenetic discrepancies between patients with and without treatment, matching epigenetic regulation with symptom amelioration may significantly advance the understanding of the etiology and treatment mechanism for CFS. EPAS1/HIF-2&alpha; is a leading candidate for an epigenetic biomarker as it responds differentially to hypoxic and normoxic conditions, which degrades more slowly in hypoxic conditions. Epigenetic regulation of EPAS1/HIF-2&alpha; in such differential conditions may be explored in HBOT experiments. In addition to HBOT as a promising treatment option for CFS symptoms, it may aid the identification of biomarkers in CFS. Further research into both outcomes is strongly encouraged.</p> 02/15/2021//m.lakotalakes.com/jprr/jprr-aid1019.php <h1>Abstract</h1> <p>Introduction: COVID-19 is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 and it was first reported in China. The aim of this study was to compare clinical features, chest CT findings and laboratory examinations of suspected COVID-19 inpatients according to RT-PCR analysis.</p> <p>Methods: Demographics, comorbidites, symptoms and signs, laboratory results and chest CT findings were compared between positive and negative groups. The study included 292 patients (134 females, 158 males) suspected of COVID-19. All statistical calculations were performed with SPSS 23.0.</p> <p>Results: 158 (54.1%) of the cases were male and 134 (45.9%) were female. Their ages ranged from 17 to 95 years, with an average of 50.46 &plusmn; 20.87. A symptom or sign was detected in 86.3% of all patients. The chest CT images of 278 patients were analyzed. Chest CT was negative in 59.2% of patients with positive RT-PCR and 43.9% of patients with negative RT-PCR results. Chest CT findings were atypical or indeterminate in 22.4% of patients with positive RT-PCR results and 20% of patients with negative RT-PCR analysis. ALP, bilirubine, CRP, eosinophil count, glucose, CK-MB mass and lactate were significantly lower in patients with positive RT-PCR test. LDH, lipase, MCV, monocyte, neutrophil count, NLR, platelet, pO2, pro-BNP, procalcitonin, INR, prothrombin time, sodium, troponin T, urea, WBC were significantly lower in patients with positive RT-PCR test results.</p> <p>Conclusion: The diagnosis of COVID-19 is based on history of patient, typical symptoms or clinical findings. Chest CT, RT-PCR and laboratory abnormalities make the diagnosis of disease stronger.</p> 01/28/2021//m.lakotalakes.com/jprr/jprr-aid1018.php & lt; h2> Abstract< / h2><p>Background: In 2004 we started a phase II trial in non-small lung cancer (NSCLC), stage III, with erlotinib followed by a combination with a platinum-based doublet in unselected patients to identify molecular subgroups benefitting from an EGFR targeting approach.</p> <p>Patients and methods: Induction with erlotinib (E, 150 mg, d1-42) was followed by three cycles of gemcitabine (G, 1250 mg/m&sup2;, d1+d8, q3w) and cisplatin (P, 80 mg/m&sup2;, d1, q3w). Patients with at least stable disease after E were treated with a GP + E combination. Induction was followed by surgery and radiation. The trial was conducted as a prospective, multi-center, open label, exploratory phase II study to determine pathological response rate (pRR), as well as secondary endpoints disease free survival (DFS) and overall survival (OS).</p> <p>Results: Of 38 prescreened patients 16 were included in the main study. Due to slow recruitment the study had to be terminated early. Combination of E and GP was well tolerated, surgery was feasible after induction therapy in 12 of 16 patients, 7/12 (58%) patients had a major pathological response (MPR). Median overall survival for patients with MPR was 57.7 months (confidence interval (CI), 37.4 to 78.0; n = 7) and for patients without MPR 11.9 months (CI, 6.4 to 17.4; n = 5). 2/16 patients had an epidermal growth factor receptor (EGFR) mutation.</p> <p>Conclusion: Before discovery of distinct molecular mechanisms in NSCLC our study was an attempt to identify clinical and pathological subgroups that would benefit from E induction. Two patients with an EGFR mutation were identified. MPR was a predictor of long term disease free and overall survival.</p> 12/30/2020//m.lakotalakes.com/jprr/jprr-aid1017.php & lt; h2> Abstract< / h2>& lt; p>哈麦丹风的季节,这是一个时期的特点是低温,干燥的空气,增加了空气污染会导致广泛的空气传播疾病和预先存在的条件恶化,应视为一段高COVID-19感染率的潜在风险。这一时期也正值圣诞节有很多庆祝活动,也可以成为COVID-19 super-spreader。现在许多尼日利亚人放弃COVID-19非药物保护措施,守卫的季节和即将到来的社交聚会激增可能迎来第二波可能更灾难性的病毒。有尼日利亚政府需要开始计划和建立新的安全保护措施和指导方针圣诞庆祝活动同时也教育和鼓励民众采取保护措施建议的专家。;/ p> 11/17/2020//m.lakotalakes.com/jprr/jprr-aid1016.php & lt; h2> Abstract< / h2><p>Spontaneous pneumomediastinum (SPM) is a rare condition, more commonly seen in patients with history of asthma, chronic obstructive pulmonary disease, infections, or drug users. Today, we face one novel virus that has cause an outbreak of acute respiratory illness, affecting over a million individuals worldwide. New knowledge is been gained of the virus and possible complications are been seen. Following, we present the case of a 71-year-old man with diagnosis of COVID-19 pneumonia complicated with spontaneous pneumomediastinum.</p> 09/16/2020//m.lakotalakes.com/jprr/jprr-aid1015.php & lt; h2> Abstract< / h2>& lt; p> & lt; strong>目的:& lt; / strong>评估的知识、态度和实践宣布在全科医生(GPs)关于阿里使用抗生素治疗的5岁以下儿童在卢本巴希。;/ p>& lt; p> & lt; strong>方法:& lt; / strong>横断面调查评估水平的知识、态度和实践有关抗生素处方67年GPs在儿科工作设置中各种医疗结构在卢本巴希市,在刚果民主共和国。数据收集从4月1日到6月30日,2020年。你们;/ p>& lt; p> & lt; strong>结果:& lt; / strong>GPs知识有限抗生素处方(平均46%的正确的8个问题的答案)。虽然他们通常关注抗生素耐药性(平均,plusmn;SD = 0.50, plusmn; 0.68), and are unwilling to submit to pressure to prescribe antibiotics to meet patient demands and expectations (mean &plusmn; SD = &ndash;1.78 &plusmn; 0.31) and the requirements to prescribe antibiotics for fear of losing patients (mean &plusmn; SD = &ndash;1.67 &plusmn; 0.47), there was a lack of motivation to change prescribing practices (mean &plusmn; SD = &minus;0.37 &plusmn; 0.94) and strong agreement that they themselves should take responsibility for tackling antibiotic resistance (mean &plusmn; SD = 1.24 &plusmn; 0.74). Multiple linear regression results showed that higher knowledge scores were associated with less avoidance of responsibility when prescribing antibiotics (&beta; = 0.919; p = 0.000).</p> <p><strong>Conclusion: </strong>To curb the over-prescription of antibiotics, it is not enough to improve knowledge in itself. The lack of motivation of physicians to change must be addressed through a systematic approach. These data show the need for interventions that support the rational prescribing of antibiotics.</p> 08/07/2020//m.lakotalakes.com/jprr/jprr-aid1014.php & lt; h2> Summary< / h2>& lt; p> & lt; strong>简介:& lt; / strong>COVID-19疾病暴发的有一个伟大的临床和微生物的影响在过去的几个月里。在preanalytical阶段,收集的样本呼吸道在适当的时刻,从正确的解剖网站是必不可少的一个快速和精确的分子诊断假阴性率不到20%。你们;/ p>& lt; p> & lt; strong>材料与方法:& lt; / strong>我们进行了描述性研究COVID-19疾病的持续负面rt - pcr检测患者的呼吸道疾病研究所(内心)在墨西哥城在2020年3月至5月期间。38例患者注册- rt - pcr测试通过鼻咽和口咽抽汲。我们与Shapiro-Wilk评估数据的分布正态性检验。非参数的数据报告与值。名义和序数变量的百分比。;/ p> <p><strong>Results:</strong> The average age of our cohort was 46 years and 52.63% were male (n = 20). Diabetes Mellitus was documented in 34.21% (n = 13) of the patients, Systemic Hypertension in 21.05% (n = 8), Obesity in 31.57% (n = 12) and Overweight in 42.10% (n = 16). Exposure to tobacco smoke was reported in 47.36% (n = 18) of the patients. The median initial saturation of oxygen was 87% at room air. The severity of the disease on admission was: mild 71.05% (n = 27), moderate 21.05% (n = 8) and severe or critical in 7.89% (n = 3) of the cases respectively. 63.15% (n = 24) sought medical care after 6 or more days with symptoms. Lymphopenia was documented in 78.94% (n = 30). Median LDH at the time of admission was 300, being elevated in 63.15% (n = 24) of the cases. The initial tomographic imaging of the chest revealed predominantly ground glass pattern in 81.57% (n = 31) and predominantly consolidation in 18.42% (n = 7). The registered mortality was 15.78% (n = 6).</p> <p>Conclusion: Patients with COVID-19 and a persistently negative RT-PCR test with fatal outcomes did not differ from the rest of the COVID-19 population since they present with the same risk factors shared by the rest of patients like lymphopenia, comorbidities, elevation of D-Dimer and DHL on admission as well as a tomographic COVID-19 score of severe illness, however we could suggest that the percentage of patients with a mild form of the disease is higher in those with a persistently negative RT-PCR test.</p> 05/30/2020//m.lakotalakes.com/jprr/jprr-aid1013.php & lt; h2> Abstract< / h2>& lt; p> & lt; strong>目的:& lt; / strong>Dysfunctional breathing (DB) refers to abnormal patterns of breathing. No gold standard exists for diagnosis. In clinical practice we regularly see children with functional breathing problems. We collected data from this patient group to gain more insight into the characteristics of children with dysfunctional breathing.</p> <p><strong>Methods:</strong> We composed a retrospective, cross-sectional study. The population consisted of children referred to a physiotherapist by a pediatrician due to suspected dysfunctional breathing. Data from 2013-2015 were collected from patient files, selected according to patterns and onset of symptoms, concomitant asthma, Nijmegen questionnaire (NQ) score, maximum exercise capacity and breathing pattern.</p> <p><strong>Results:</strong> A total of 201 patients were included in the study, 66% of whom were female. The mean age was 13.9 years; 26% of the children were overweight. The most frequently reported symptoms were breathlessness, chest pain/tightness and dizziness.&nbsp; Fifty-two percent had a NQ score &ge; 23, mainly female. Twenty-eight percent of the children scored &lt; p5 for their age on maximum exercise capacity; this proportion was substantially higher among males. Of the total population, 78% scored &lt; p50 for their age. Subgroups with a higher body mass index (BMI) showed lower maximum exercise capacity. Children presenting with pulmonary symptoms were primarily misdiagnosed with asthma.</p> <p><strong>Conclusion:</strong> Dysfunctional breathing is a common cause of respiratory complaints. Most children with dysfunctional breathing have a high BMI and are in poor physical condition, which suggests a clinically relevant comorbidity and possible options for therapy. Children are often falsely diagnosed with asthma; better recognition will decrease unnecessary medication use.</p> 07/24/2019//m.lakotalakes.com/jprr/jprr-aid1012.php & lt; h2> Abstract< / h2>& lt; p> & lt; strong>简介:& lt; / strong>肺结核是结核分枝杆菌引起的一种传染性疾病(科赫的芽孢杆菌),并提出长期进化影响肺部频繁。你们;/ p>& lt; p> & lt; strong>目标:& lt; / strong>分析,在Maranh& atilde; o,流行病学肺结核患病率在2014年和2016年之间灵活;/ p>& lt; p> & lt; strong>材料与方法:& lt; / strong>纪录片和描述性研究二级数据库中收集的数据的日期,流行病学信息和发病率在2014年和2016年之间灵活;/ p>& lt; p> & lt; strong> Results< / strong>: 3897例肺结核的Maranh& atilde; o记录。受影响最严重的年龄范围是15至59岁,共3111例,对性别;60到79年,总共577例。;/ p> <p><strong>Conclusion</strong>: Tuberculosis affects more adolescent males from adolescence to old age, and it is necessary to promote knowledge of the disease for the population in order to advance in the control of the same and obtain satisfactory clinical results.</p> 06/04/2019//m.lakotalakes.com/jprr/jprr-aid1011.php <h2>Introduction</h2> <p>Asthma is a highly prevalent airway disease with multiple phenotypes [1,2]. Adult-onset eosinophilic asthma is a severe asthma subtype associated with more frequent and severe exacerbations, the development of persistent airflow limitation and a poorer quality of life. This type of asthma is much more difficult to control than other asthma subtypes, requiring high doses of inhaled or even oral corticosteroids (OCS) [3,4].&nbsp;Recently, several new monoclonal antibody therapies have been approved for eosinophilic severe asthma, including anti-IL-5 treatment. IL-5 is essential for eosinophilic maturation and survival [5] and anti-IL5 treatment has markedly reduced asthma exacerbations with sparing of OCS use in patients with eosinophilic asthma [6]. Eosinophilic asthma is frequently associated with chronic rhinosinusitis and/or nasal polyposis [7], suggesting that a similar eosinophilic inflammatory process might drive both conditions. Eosinophilic otitis media (EOM) also might fit in this concept, showing remarkable similarities with asthma and nasal polyposis. The disease was first reported in 1994, but only since 2011 diagnostic criteria for EOM were identified. If a patient shows otitis media with effusion or chronic otitis media with eosinophil-dominant effusion (major criterion) and is being positive for &ge;2 items of the 4 minor criteria (highly viscous middle ear effusion, resistance to conventional treatment, association with asthma, association with nasal polyposis) he is diagnosed as having EOM. Eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome must be excluded [8].</p> 01/18/2019//m.lakotalakes.com/jprr/jprr-aid1010.php <h2>Review</h2> <p>With the invention of the stethoscope, in the early 1800s, a better diagnosis of heart and lung disorders was opened up. Through the stethoscope&#39;s 200-year history, there has been a significant development of the stethoscopy from the use of the simple monaural earpiece to the binaural stethoscope, followed by the electronic stethoscope, which, together with other studies, has enabled a thorough diagnosis of these disorders. Here is a glimpse of this story.</p> <p><strong>The cross-border investigation</strong></p> <p>Far back in time, it has been clear that the function of the heart and lungs played an important role in maintaining life. By tapping with the finger (percussion) and putting the ear to the patient&#39;s chest (auscultation), it could hear sound from the body telling about the patient&#39;s condition, especially about the presence of fluid or air-filled organs. Auscultation is already described in the Corpus Hippocraticum, in the Diseases II section [1]. The doctor puts the ear to the chest of a patient with water sores, to hear the pain as a wine vinegar from the lungs - or the doctor grabs the patient about the shoulders, shakes him and places his ear to his chest to hear in which side his pleuritis is sitting. Since then, auscultation seems to have been partially forgotten, although it has probably been known by Ambroise Par&eacute; and William Harvey [2]. It was not until the late 1700s that it became an important diagnostic aid, just like the pulse clock and the medical thermometer [3 p. 277]. Here, Joseph Leopold Auenbrugger (1722-1809) is considered to be the father of the modern physical examination, which is based on percussion. Percussion he performed by knocking direcly on the thorax with the finger or cupped hands. His discovery of the percussion sounds from the chest during inhaling and exhaling originates from his work in 1760 at the Vienna Military Hospital [4]. In 1761, His little book on thoracic percussion revealing thoracic diseases appeared in 1761 [3p.271], which in 1808 was translated into French by the Parisian physician Jean Nicolas Corvisart des Marets (1755-1821). This contributed to the French doctors starting to use percussion and ausculation more routinely [5].</p> <p>The limitation of simple auscultation was the fact that the sound was weak and incomplete and therefore there was a need for improved sound quality. In addition, the direct contact with the patient&#39;s body could seem insulting.</p> 12/31/2018//m.lakotalakes.com/jprr/jprr-aid1009.php & lt; h2> Abstract< / h2><p>Blood plays an important role in oxygen absorption and its transfer to organs and tissues in vertebrates, as well as in a number of invertebrate species. Numerous interactions between cellular and non-cellular blood components constantly occur. A special role in these interactions belongs to erythrocytes and leukocytes, between which oxygen is constantly exchanged and activated, which we showed directly in whole blood.&nbsp;Blood is a liquid tissue, which is a complex cooperative system and has many inherent functions and the most important one is the ability to maintain the homeostasis of the body. Our experience has shown that despite its high optical density, undiluted blood of humans and animals can be a source of radiation due to the transformation of the energy of electron-excited (EEE) states and secondary processes occurring in the whole blood system. Parameters of this radiation - ultra-weak photons emission (UWPE) from blood - depend upon its physiological properties and reflect the physiological state of a donor. Analysis of UWPE from non-diluted blood is a simple and sensitive method that allows to monitor the course of treatment of a patient. In spite of high opacity of non-diluted blood it may be a strong source of UWPE both in the presence and absence of UWPE enhancers. Analysis of patterns of UWPE from blood reveals its highly non-linear, stable non-equilibrium and cooperative properties. Characteristic of a living system.</p> 10/27/2018//m.lakotalakes.com/jprr/jprr-aid1008.php & lt; h2> Opinion< / h2>& lt; p>慢性阻塞性肺疾病(COPD)是死亡的第三大原因,其患病率和发病率也与吸烟相关行为[1]。慢性阻塞性肺病仍然是一个多因素引起的慢性炎症和进步疾病代理包括环境污染[2]。除此之外,新兴的是内源性表观遗传因素引起的生活方式和环境[3]可能在疾病的发病机理中发挥作用[4]。;/ p>& lt; p>在过去的几年,一些作者似乎表明,低维生素D水平与慢性阻塞性肺病的增加表现[5]。此外,多中心、双盲、随机对照试验证明,维生素D补充剂预防中度或严重恶化的疾病,但不是由上呼吸道感染[6]。然而,低水平的维生素D可以扩展到其他许多疾病,包括多发性硬化症、糖尿病、结肠直肠癌、头痛或吸毒(7 - 11)。此外,同样重要的是要记住,维生素D缺乏在高纬度地区很常见,比如北欧,新西兰,美国北部和加拿大,较弱的紫外线B射线不能产生足够的维生素D。最后,方法论的因素(使用低灵敏度方法)可能导致误导性循环维生素D水平的评价。在任何情况下,在这里我们要提醒,维生素D在免疫[12]有一个基本的角色。特别是,据报道,维生素D能够转变促炎辅助细胞1 -抗炎辅助细胞2 [13]。 Therefore, benefits of vitamin D supplementation in chronic diseases which directly or indirectly affect immune system are obvious. Today, the burden of COPD in never smokers is higher than previously believed. Therefore, more research is needed to unravel the characteristics of non-smokers COPD [1]. Notably, vitamin D levels are reported to be significantly lower in smoker&rsquo;ssubjects than in non-smokers ones [14]. Therefore, low plasma vitamin D levels in COPD seems to be more a causality than a correlation.</p> 08/29/2018//m.lakotalakes.com/jprr/jprr-aid1007.php & lt; h2> Abstract< / h2>& lt; p> & lt; strong>背景:& lt; / strong>糖尿病是一种疾病和死亡的主要原因。肺功能测试击球时扮演了一个关键的角色在流行病学研究调查发病率、自然历史和肺病。你们的因果关系;/ p>& lt; p> & lt; strong> Methods< / strong>:横断面研究的国家Ribat教学医院和行动中Abualiz专门在喀土穆州糖尿病中心测量呼吸肌肉力量在31个糖尿病患者(病例组)和30名非糖尿病患者(对照组)。肺功能测试是衡量使用数字Spirometer-Micro-Plus版本。;/ p>& lt; p> & lt; strong> Results< / strong>:糖尿病患者肺功能参数之间及其与对照组没有显著差异之间的FVC、FEV1、FEV1 / FVC的。然而,糖尿病患者显示显著减少病人。;/ p>& lt; p> & lt; strong> Conclusions< / strong>:锻炼和控制糖尿病有助于保持正常的呼吸肌肉力量。持续合理的运动与控制好强烈推荐对所有糖尿病患者。你们;/ p> 08/17/2018//m.lakotalakes.com/jprr/jprr-aid1006.php & lt; h2> Abstract< / h2>& lt; p> & lt; strong> Background< / strong>: Macitentan明显不能改善患者的肺血流动力学和生存原发性肺动脉高压(PPH)。其有益效果,然而,可能会削弱由于贫血和周围水肿等不利影响。肺动脉高压(PAH)是一个重要的先天性心脏病(CHD)的结果。它的存在和严重程度与发病率和死亡率的增加有关。我们试图评估的有效性macitentan晚发性肺动脉高压患者的心房中隔缺损手术后在我们的中心。;/ p>& lt; p> & lt; strong> Methods< / strong>:单剂量的影响macitentan(10毫克)肺血液动力学功能容量检查四晚发性肺动脉高压患者心房中隔缺损手术后。;/ p>& lt; p> & lt; strong> Results< / strong>: macitentan明显提高平均肺动脉压(肺动脉平均)、心输出量(CO)、三尖瓣环平面收缩偏差(TAPSE)、右心室收缩波(RVS&,), 6分钟步行试验和中位数水平以上病人水平与治疗前相比。;/ p>& lt; p> & lt; strong> Conclusions< / strong>: Macitentan可用于分流手术后晚发性肺动脉高压患者尤其是心房中隔缺损。;/ p> 09/28/2017//m.lakotalakes.com/jprr/jprr-aid1005.php & lt; h2> Abstract< / h2>& lt; p>化疗是癌症的主要治疗方法之一。然而,化疗药物通常遭受贫穷的药品属性限制他们使用。amp;,靶向治疗药物开发专门针对癌细胞的变化,帮助这些细胞生长。这些药物通常当标准化疗药物不工作,他们经常有严重的副作用少,最常用于晚期癌症。本文的目的是提供一个概览的16 fda批准的靶向治疗药物来治疗非小细胞肺癌。;/ p> 09/27/2017//m.lakotalakes.com/jprr/jprr-aid1004.php & lt; h2> Abstract< / h2>& lt; p>两个最近的腊八/ ICS组合治疗持续性哮喘的Fluticasone糠酸盐/ Vilanterol 92/22,μ;g (Ellipta)和二丙酸倍氯米松/ Formoterol 100/6,μ;g (Nexthaler)。; / p>& lt; p> & lt; strong> Objective< / strong>:比较每日一次/每天两次Vilanterol结合倍氯米松/ Formoterol协会中度哮喘、生活质量和肺功能灵活;/ p>& lt; p> & lt; strong> Methods< / strong>:中度哮喘治疗的患者40倍氯米松/ Formoterol 100/6,微;g或Fluticasone / Vilanterol 92/22,微;g。我们重估病人的肺功能和哮喘控制测试,在4、8、12周评估两组之间的任何差异。4周后,31的四十个病人的呼吸功能评估在预先确定的时间间隔灵活;/ p>& lt; p> & lt; strong> Result< / strong>:患者在倍氯米松/ formoterol FEV1提出的78%的平均值在79.1%的第三次和最后的检查,而74.5%和75.8%的病人在治疗卡松/ vilanterol (p 0.01)。平均值IC和mmef25 - 75%患者更高倍氯米松/ formoterol卡松/ vilanterol相比。呼吸困难的第三个观点的差异。夜间症状和救援药物的使用有显著差异,除了一开始。 For the perception of control by patients, there was a difference in the two groups at the beginning, after 4 and 8 weeks. Total ACT score showed a significant difference after 4, 8 and 12 weeks. In the group treated with beclomethasone/formoterol FEV1 value was significantly higher at a distance of four hours after drug administration (p 0.04) and after the second dose (p 0.02) compared with the group treated with fluticasone/vilanterol.</p> <p><strong>Discussion</strong>: Patients in treatment with beclomethasone/formoterol showed improved asthma control and nocturnal symptoms and more stable respiratory function compared with patients receiving fluticasone/vilanterol.</p> 06/23/2017//m.lakotalakes.com/jprr/jprr-aid1003.php & lt; h2> Report< / h2><p>Bronchiolitis obliterans (BO) is an infrequent clinical syndrome characterized by the chronic obstruction of small airways due to fibrosis [1]. Intravenous immunoglobulin (IVIG) could be used for treatment while underlying immune mechanisms in the pathogenesis of BO exist [2]. Here, we present two children with BO due to adenovirus infection whose complaints resolved after IVIG replacement.</p> 06/19/2017//m.lakotalakes.com/jprr/jprr-aid1002.php & lt; h2> ABSTRACT< / h2>& lt; p>通常用于钡radiocontrast检查消化系统的粘膜吸收是有限的。大量钡愿望是一种罕见的并发症,尤其是当没有解剖或神经赤字。根据钡浓度会导致各种肺的效果。文献回顾的时候,钡愿望可能无症状或在大量致命。很少,大量的硫酸钡吸进肺,没有文献研究多久这是发生。你们;/ p>& lt; p>我们现在大量钡的愿望在这个话题。此案patient&有关,年代诊断esophagography投诉吞咽问题。大量钡愿望couldn&不注意,因为缺乏急性症状和手术病人经历了先前的胃肠道。当病人应用小儿胸部疾病综合医院三个月后,由于考试和深度研究明白的情况是大量钡抱负。 The patient was directed to our center because there was a radiological appearance of bone density signs on chest X-ray. Such a complaint was not reported by the family neighter in his biography, nor was written in the epicrisis. We will share acute and chronic changes in the lungs, diagnosis and treatment approaches of this case. The infant who has ileostomy was previously operated because of necrotizing enterocolitis. And also still has severe gastro-esophageal reflux and under conservative and medical treatment, a possible fundoplication surgery is planning.</p> 05/31/2017//m.lakotalakes.com/jprr/jprr-aid1001.php & lt; h2> Report< / h2>& lt; p>氧疗法是主要在血氧过低的支持性治疗呼吸衰竭和历来交付使用低和高流设备。然而,这些设备可以提供的最大流速是有限的,因为热量和湿度提供给气体管理不足。低流设备,如鼻腔插管,常规面罩和水库袋交付15 L /分钟的流量管理更多的变量氧气分数(供给),根据patient&,呼吸模式,吸气流量和峰值特征的设备。传统高流量设备,例如文丘里式面具,利用恒流的氧气通过精确大小的港口,吸入空气,利用伯努利原理,提供一个更不断启发氧气分数。然而,他们比鼻插管不容忍,因为他们不太舒适,气体的加湿和加热不足交付[1]。;/ p>& lt; p>在过去的二十年里,新设备开发管理高湿润和加热流经鼻插管(HFNC),也允许交付的氧气供给高达100%。在文献中,这种技术也被称为迷你CPAP(持续气道正压),底吹气,高鼻流通风,高流量氧气疗法,和高氧流鼻插管治疗[2]。;/ p>