//m.lakotalakes.com/hcg Heighpubs开放获金博宝app体育取期刊上 en - us 08/17/2021//m.lakotalakes.com/hcg/acgh-aid1030.php & lt; h2> Abstract< / h2><p>Non-alcoholic fatty liver disease (NAFLD) is a condition that is associated with cirrhosis and hepatocellular carcinoma, and is increasing in prevalence worldwide. Sleep disruptions are commonly seen in NAFLD, and the disease process is associated with sleep disorders, including obstructive sleep apnea, circadian rhythm disorders, and insufficient sleep. The intermittent hypoxia seen in obstructive sleep apnea may contribute to fibrotic changes in the liver.</p> <p>A major component of this linkage may be related to gut microbiome changes. One notable change is increase in Bacteroidetes/Firmicutes ratio, and decrease in flora that ferment fiber into anti-inflammatory short-chain fatty acids. Several therapeutic options exist for NAFLD that target both sleep and NAFLD, including non-pharmacological factors, such as lifestyle modification (mainly diet and exercise). Pharmacological options include melatonin, Vitamin E, thiazolidinediones, and fecal microbiota transplantation.</p> <p>Core tip</p> <p>The pathogenesis of non-alcoholic fatty liver disease is closely tied to sleep and circadian rhythm abnormalities, through shared inflammatory pathways and altered metabolism. This review explores the pathogenesis of NAFLD in the context of sleep and circadian abnormalities. The associated inflammatory response is linked to changes in gut-microbiome interactions that contribute to the disease process. Understanding of this linkage has implications for various therapies for disease mitigation.</p> 07/16/2021//m.lakotalakes.com/hcg/acgh-aid1029.php & lt; h2> Abstract< / h2><p>Background: Intestinal obstruction (IO) is defined as a partial or complete blockage of the bowel that results in the failure of intestinal contents to pass through. It is a common cause of emergency surgical problems. IO has been the leading cause of acute abdomen in several African countries.</p> <p>Objective: To assess surgical management outcome of intestinal obstruction by IESO professionals and its associated factors of intestinal obstruction in surgically treated patients at South Wollo zone.</p> <p>Method: A cross-sectional study was done on 216 patients &lsquo;the data was collected from medical cards of the patient by using a pretested data abstraction format. Three nurses were involved in the process of data collection. The collected data was cleaned, coded and analyzed by SPSS version 23 statistical package. First descriptive statics was done for categorical and analyzed using frequencies and percentage. Multivariable logistic regression models was used to determine the association factors on the management outcome of intestinal obstruction when p - value &lt; 0.05 and the strength of statistical association was measured by adjusting odds ratio and 95% confidence interval. Statistical significance was taken at p - value &lt; 0.05.</p> <p>Results: From all study participants about 177 (82%) of them had good surgical outcome. Study participants who were managed by 1-3 years of work experience of IESO {(p = 0.004, AOR (95% CI) = 7.2[1.89, 27.68]}, preoperatively diagnosed as small bowel obstruction {(p = 0.001, AOR (95% CI) = 4.5[1.91, 10.40], Surgery conducted at day time<br /> {(p = 0.03, AOR (95% CI) = 2.8[1.06, 7.16]} had shown positive association with management outcome of intestinal obstruction conducted by IESO professionals.</p> <p>Conclusion and recommendation: Majority patients with intestinal obstruction had good surgical outcome done by IESO professionals. Year of experience of IESO Workers, preoperative diagnosis and time of surgery of the respondents had shown positive association for the occurrence of chronic liver disease whereas. In this study we can conclude that surgeries of intestinal obstruction conducted by IESO professionals are as good as intestinal obstruction surgeries conducted by physicians so there is a need to train more IESO professionals to deliver decentralized surgical service for rural areas.</p> 07/09/2021//m.lakotalakes.com/hcg/acgh-aid1028.php & lt; h2> Abstract< / h2><p>Functional dyspepsia (FD) is a prevalent global health concern increasing with years. Inspired by the Traditional Chinese Medicine (TCM) liver-stomach disharmony syndrome in order to find a quick natural alternative treatment, a Ferula asafoetida-Silybum marianum (Asdamarin&trade;) combined extract has been developed and proved its rapid efficiency and its safety with a 7-day randomized, double-blind, placebo-controlled pilot study (CTRI/2018/05/013993 dated 21/05/2018) conducted on 70 healthy human volunteers (aged 18&ndash;60 years) supplemented with 250 mg / twice a day of either a placebo or Asdamarin&trade;. Subjects were evaluated from baseline to the end of the study (EOS) through changes in Gastrointestinal Symptom Rating Scale (GSRS), changes in Glasgow Dyspepsia Severity Score (GDSS) and changes in the short form of Nepean Dyspepsia Index (NDI-SF) for Quality of Life. Compared to the baseline a significant reduction (p &lt; 0.001) of GDSS questionnaire score was noted in the Asdamarin&trade; group (from 5.66 &plusmn; 3.1 at baseline to 5.09 &plusmn; 2.8 at the End Of Study (EOS)) compared to placebo group (from 2.77 &plusmn; 1.3 baseline to 2.69 &plusmn; 1.3 EOS), a significant decrease (p &lt; 0.001) of GSRS score noted in the Asdamarin&trade; group (from 32.11 &plusmn; 8.6 baseline to 19.11 &plusmn; 5.4 EOS) compared to the placebo group (from 25.23 &plusmn; 3.6 baseline to 23.2 &plusmn; 4.9 EOS), and a significant reduction (p &lt; 0.001) of NDI-SF scoring was noted in the Asdamarin&trade; group (from 15.74 &plusmn; 4.1 baseline to 11.54 &plusmn; 2.1 EOS) compared to placebo group (from 12.54 &plusmn; 3.2 baseline to 11.63 &plusmn; 2.6 EOS). Asdamarin&trade; has been found safe and very well tolerated during the study.</p> 03/17/2021//m.lakotalakes.com/hcg/acgh-aid1027.php & lt; h2> Abstract< / h2><p>Biliary cystadenoma is a rare cystic tumor of the liver. It has a high recurrence rate and malignant transformation risk in middle-aged women. Pre-operative diagnosis is difficult because of the lack of clinical, biological and radiological specificity. The confirmation of the diagnosis is made by the histopathological examination. Complete surgical resection is preferred because of the high risk of malignant transformation and recurrence.</p> 02/15/2021//m.lakotalakes.com/hcg/acgh-aid1026.php & lt; h2> Abstract< / h2><p>Radiofrequency ablation is one of the most commonly used therapies for potentially curative small hepatocellular carcinoma. Although radiofrequency is usually a safe procedure, severe and potentially fatal complications can happen. This is a case of a 72 years old woman with cirrhosis secondary to Metabolic Associated Fatty Liver Disease (MAFLD), who presented recurrent hydrothorax after treating hepatocellular carcinoma (HCC) with radiofrequency ablation (RFA), and in which diaphragmatic perforation was subsequently diagnosed. We reviewed the differential diagnosis and management in a pleural effusion after a radiofrequency procedure. Although diaphragmatic perforation is an uncommon complication after RFA procedure, this case aims to help clinicians being aware of non-habitual complications.</p> 02/01/2021//m.lakotalakes.com/hcg/acgh-aid1025.php & lt; h2> Abstract< / h2><p>Introduction: Drug-induced Hepatotoxicity and biologic drugs have historically been challenging in IBD. We aim to study the prevalence of hepatotoxicity in adult patients using biologic medications.</p> <p>Methodology: With the guidelines described by PRISMA-P, a detailed search strategy for each electronic database was developed based on PubMed, Medline, and Embase. We include RCTs that assessed the efficacy and hepatotoxicity of biologics in IBD patients. Hepatotoxicity was defined as AST and/or ALT &gt;2x upper limit of normal or cholestasis. The Odds ratio (OR) was calculated with a 95% confidence interval (CI). Heterogeneity was assessed using the chi2 test and the I2 statistic.</p> <p>Results: 862 records identified in total. After removing the duplicates 564 records were left for review. Four studies did not report on how participants were randomized to treatment groups or how allocation concealment was achieved, we rated these studies at unclear risk of bias for these domains. There was no presence of any heterogeneity among studies by (Chi2= 2.21, df = 6, p = 0.90, and I2 = 0%). Our meta-analysis was conducted on the fixed effects model, with the (0.770, 95% CI [-0.630, 0.957], and p = 0.02). Hepatotoxicity was not related to any TNF-&alpha; antagonist. Thiopurine induced liver injury occurred more frequently within the first months of treatment, 50% of cases within the first 3 months (11.4% vs. 2.3%, p &lt; 0.05).</p> <p>Conclusion: When hepatotoxicity occurred, the treatment was withdrawn in thirty one percent of patients. This group of patients had a dose-dependent hepatotoxicity rather than an immunologic hepatitis.</p> 01/11/2021//m.lakotalakes.com/hcg/acgh-aid1024.php & lt; h2> Abstract< / h2>& lt; p>急性肝功能衰竭(ALF)的儿童是一种严重的疾病,死亡率很高。当前治疗策略仍有缺陷,许多情况下死肝移植时不可用。类固醇治疗的现有协议改进的存活率甲肝病毒(HAV)有关的阿尔夫。然而,仍有高死亡率non-HAV病例。干细胞疗法(SCT)在实验动物与阿尔夫,几个成人研究acute-on-chronic肝功能衰竭。儿童没有以前SCT的试验测试与阿尔夫。儿童缺乏SCT应用阿尔夫可能是由于一些问题。这些可能与安全、来源、管理路线,最佳剂量、疗效和生存。提出,如果这些障碍可能是未来治疗已得到充分的研究和解决灵活;/ p> 10/20/2020//m.lakotalakes.com/hcg/acgh-aid1023.php <p>Coronavirus infections have caused outbreaks in humans: SARS-COV ((Severe Acute Respiratory Syndrome) and MERS-CoV (Middle East Respiratory Syndrome) resulting in significant mortality and morbidity.</p> 10/05/2020//m.lakotalakes.com/hcg/acgh-aid1022.php & lt; h2> Abstract< / h2><p>Purpose: Percutaneous abscess drainage (PAD) is the first-line approach for abscess in Crohn&rsquo;s disease (CD) since it procrastinates or avoids surgery especially in postoperative abscesses [within 30 days post-operative (p.o.)]. We retrospectively evaluated the effectiveness, complications and outcome after PAD in postoperative and spontaneous abscesses and factors influencing the outcomes.</p> <p>Methods: We performed PAD in 91 abscesses, 45 (49,5%) postoperative and 46 (50,5%) spontaneous.</p> <p>We defined the overall success (OS) as clinical (CS) and technical success (TS) when imaging documented the resolution of the abscess with no surgery within 30 days.<br /> Conversely, patients without abscess at the time of surgery, were considered as TS but clinical failure (CF).</p> <p>We also analyzed the overall failure (OF) defined as CF with or without technical failure (TF).</p> <p>Overall technical success (OTS) was OS plus TS. Complications were classified as major and minor according to the Interventional Radiology Criteria.</p> <p>Results: In postoperative abscesses we found 91% OS, 9% OF, no TF and 100% OTS.<br /> In spontaneous abscesses we found 33% OS, 67% OF, 6.4% TF, 95,6% OTS.</p> <p>A total abscess resolution was achieved in 97,8% of patients. No major complication occurred; only 1 case of minor complication. Factors statistically influencing the outcome were postoperative vs spontaneous collections (OF: 9% vs. 67%, p &lt; 0.0001), multiloculated vs uniloculated collections (OF: 38% vs. 1%, p &lt; 0.0001) and upper abdominal vs lower location (OF: 13% vs. 25%, p &lt;0.05).</p> <p>Conclusion: Our data confirms the safety and effectiveness of PAD even in cases needing surgery within 30 days; most remarkable, PAD allows avoidance of early reoperation in almost all the patients with postoperative abscess.</p> 06/04/2020//m.lakotalakes.com/hcg/acgh-aid1021.php & lt; h2> Abstract< / h2>& lt; p>炎症性肠病(IBD)相关关节炎叫做Enteropathic关节炎(EA)之间的分类群Spondyloarthritis (SpA),因为它表示是可变的。当前的趋势是将其分类为autoinflammatory与其自身免疫性疾病,因为没有抗体尚未被确认。生物标志物的研究(BM)与早期识别,因此,将帮助我们提供早期治疗、影像学进展之前,这将使提示识别疾病的表型。包括42个病人患有炎症性肠病,其中48%是女性;研究小组的平均年龄为48.12岁,plusmn;5.02(95%置信区间)。疾病的进化的平均时间是37.57,plusmn;14.28个月;大多数病人指的风湿病学家有诊断溃疡性结肠炎(83%)。 According to our analysis, we were able to determine that the three most significant variables influencing the development of sacroiliitis were: Lactoferrin, ANCA and HLA B27 (p &lt; 0.5). The variable that can be ruled out because of its almost neglectable contribution was fecal calprotectin.</p> 06/02/2020//m.lakotalakes.com/hcg/acgh-aid1020.php & lt; h2> Abstract< / h2><p>Hepatocellular carcinoma (HCC) is characterized by high morbidity, high recurrence, and high mortality rates. In China, the morbidity of HCC is fifth among all malignant tumors and HCC is the third most common cause of cancer-related deaths. Most HCC patients also have liver cirrhosis. Surgery is the sole curative method for HCC; however, many patients are diagnosed with HCC during its advanced stages so radical resection can no longer be performed. Therefore, the proportion of patients who undergo radical hepatectomy is less than 30%. Patients with mildly advanced HCC cannot undergo hepatectomy and thus transcatheter arterial chemoembolization (TACE) and/or biological targeted therapy are alternative options. However, data on the effects of TACE therapy or biological targeted therapy are limited. Therefore, an investigation of multimodal and individualized treatments is critical to ensure the best treatment. In June 2018, we treated an advanced HCC patient with multiple metastases and right portal vein tumor thrombus. The patient exhibited partial remission after undergoing treatment with TACE and crizotinib capsules for 1 month. The case and a literature review are reported here.</p> 05/21/2020//m.lakotalakes.com/hcg/acgh-aid1019.php & lt; h2> Abstract< / h2><p>Acute pancreatitis is inflammation of the pancreas that may be accompanied by a systemic inflammatory response which results in impairment of the functioning of various organs, systems. Pancreatitis associated vascular complications very often cause morbidity and mortality. There are various cardiovascular complications like shock, hypovolemia, pericardial effusion, and sometimes ST&ndash;T changes in the electrocardiogram (ECG) presenting as acute myocardial infarction (AMI). Acute myocardial infarction complicating acute pancreatitis has rarely been studied and the exact process of myocardial injury still remains unclear. We here report a case of Acute Pancreatitis associated with acute myocardial Infarction.</p> 05/21/2020//m.lakotalakes.com/hcg/acgh-aid1018.php & lt; h2> Abstract< / h2>& lt; p>有越来越多的证据表明,食管胃食管疾病影响的微生物,细菌共生体的口咽,胃和结肠被认为是一个在modulatiing发病机理中的作用。这些新兴的假设是基于观察到的变化在食管的构成我¬‚ora,值得注意的是,重复的观察:1。有丰富的革兰氏阳性bBacteria健康的食道。2更革兰氏阳性普遍。食管人口变得越来越革兰氏阴性细菌和疾病进展。与这种转变更加克-患病率增加潜在的抗原的存在脂多糖(LPS)。免疫反应性的有限合伙人内毒素认为促进炎症和疾病易感性。;/ p>& lt; p>食道的常见疾病的发病机制如胃食管反流病(GERD),食管蠕动障碍(失弛缓性),嗜酸性食管炎(EoE) Barrett&,年代食道(是),和食道癌,是行之有效的。新兴数据显示,然而,这些都是表现为一种免疫介导的炎症级联,由dysbiotic繁殖状态。 Thereby, the ability of the healthy &ldquo;normative state&rdquo; to protect against foreign bacteria is compromised. This dysbiosis thereby can create adverse inflammatory or immunoregulatory responses with progression of disease.</p> <p>In the normal healthy state, the esophageal microbiome is constituted in-part, by a multitude of gram positive bacteria, many of which produce antibacterial peptides called bacteriocins. Bacteriocins are selective and used to maintain population integrity by killing off foreign bacteria. When the &ldquo;normative biome&rdquo; is interrupted (e.g. antibiotics, medications, diet, environmental factors), the constitutional changes may allow a more hospitable imbalance favoring the proliferation of opportunistic pathogens. Therefore it seems rational that defining, perhaps that defining, perhaps cultivating, a protective bacterial community that could help prevent or mitigate inflammatory diseases of the esophagus. Furthermore, in conjunction with evidence demonstrating that some bacteriocins are cytotoxic or antiproliferative toward cancer cell lines, further exploration might provide a rich source of effective&nbsp; peptide-based drug targets.</p> <p>Therapeutic options targeting the microbiome, including prebiotics, probiotics, antibiotics and bacteriocins, have been studied, albeit the attributable effects on the esophagus for the most part, have been unrecognized by clinicians. This review focuses on the current knowledge of the involvement of the microbiome in esophageal diseases (most notably GERD/Barrett&rsquo;s esophagus/esophageal cancer) and identifies emerging new concepts for treatment.</p> 05/13/2020//m.lakotalakes.com/hcg/acgh-aid1017.php <p>Familial adenomatous polyposis is an autosomal dominant syndrome of variable penetration and constitutes the second frequent inherited syndrome enunciating the emergence of a colorectal carcinoma.</p> 04/07/2020//m.lakotalakes.com/hcg/acgh-aid1016.php & lt; h2> Abstract< / h2><p>Celiac disease affects 1% of the world population; however it is under diagnosed in UAE. The disease has many clinical manifestations, ranging from severe malabsorption to minimally symptomatic or non-symptomatic presentation. Hypocalcaemia is a common finding in celiac disease and could be the only presentation of the disease; however hypercalcemia has been previously reported in patients with celiac disease either due to primary hyperparathyroidism or tertiary hyperparathyroidism due to prolonged hypocalcaemia. A normal calcium level on the other hand in patients with untreated celiac disease who also have primary hyperparathyroidism can be due to interplay of these two conditions and may delay the diagnosis of primary Hyperparathyroidism. We report the very first case from our practice in UAE with untreated celiac disease and normal calcium level at presentation, where a diagnosis of primary hyperparathyroidism was not entertained initially. Patient went on gluten free diet which then caused normalization of intestinal abnormalities and likely calcium absorption manifesting as hypercalcemia on subsequent labs. This led to further work up and finally the diagnosis of Primary hyperparathyroidism due to parathyroid adenoma.</p> 04/06/2020//m.lakotalakes.com/hcg/acgh-aid1015.php & lt; h2> Abstract< / h2>& lt; p> & lt; strong>简介:& lt; / strong>Pancreatic pseudocysts (PPs) are mostly delayed complications of acute or chronic pancreatitis and trauma. Pancreatic pseudocysts are usually managed by supportive medical treatment without surgical procedure. All the surgical interventions (percutaneous, endoscopic or surgical approaches) are based on the location, size, symptoms, complications of the pancreatic pseudocyst and medical condition of the patients. Recently, laparoscopic cystogastrostomy has become most appropriate approach especially for retrogastric pancreatic pseudocysts. In this study, we would like to report results of laparoscopic anterior transgastric cystogastrostomy by using linear articulated endo GIA stapler (Covidien medium thick purple) and versa-lifter (versa lifter&reg;, laparoscopic retractor, manufactured by protomedlabs, France) in 14 pancreatic pseudocysts patients.</p> <p><strong>Methods:</strong> We retrospectively analyzed data of patients with pancreatic pseudocysts treated by laparoscopic anterior transgastric cystogastrostomy from September 2010 to October 2014. All of the patients were controlled for the recurrence of pancreatic pseudocysts in February 2017.</p> <p><strong>Results:</strong> 14 patients with pancreatic pseudocysts were managed by laparoscopic anterior transgastric cysto-gastrostomy. Conversion was performed in only one patient (7%). There were no symptoms and signs of recurrence of pancreatic pseudocyst during on average 43.6 months follow up time.</p> <p><strong>Conclusion:</strong> Laparoscopic cystogastrostomy by using articulated linear endo-GIA stapler and versa-lifter is a safe and effective method for management of appropriate retro-gastric pancreatic pseudocysts.</p> 02/05/2020//m.lakotalakes.com/hcg/acgh-aid1014.php & lt; h2> Abstract< / h2><p>Heterotopic gastric mucosa (HGM) is an islet of gastric mucosa within the esophageal mucosa. These lesions can sit throughout the digestive tract and rarely in the upper third of the esophagus. The pathophysiology of HGM remains poorly understood.</p> <p>Our study aims to estimate the prevalence of HGM, clinical signs, endoscopic, microscopic aspects and different epidemiological factors associated.</p> <p>All patients from a single endoscopy center with HGM of the upper third of the esophagus were included over a 5-month evaluation period. All lesions seen in endoscopy were confirmed by histological analysis.</p> <p>The prevalence was 1.3% with a clear male predominance. 80% of patients were symptomatic and received medical treatment, clinical evolution was good. No case of dysplasia was identified and no complication was observed.</p> <p>Due to insufficient data in the evolutionary literature, the management of HGM remains debated and could resemble that of Barett&rsquo;s esophagus for monitoring and therapeutic management, particularly in the event of symptoms or dysplasia.</p> 12/05/2019//m.lakotalakes.com/hcg/acgh-aid1013.php & lt; h2> Abstract< / h2>& lt; p> & lt; strong>简介:& lt; / strong>液体管理是治疗急性胰腺炎(AP)的基石,但适当的速度和体积仍是有争议的。我们的目标是评估积极的角色在AP患者。你们水化;/ p>& lt; p> & lt; strong>方法:& lt; / strong>我们回顾性综述和分析279住院病人的美联社。严重程度是由亚特兰大修订分类;验证临床分数也计算基于临床信息表示。我们提取接收到的液体量在6、12、24和48小时后表示。激进的水合作用被定义为数量高于10毫升/公斤丸随后注入1.5 ml / kg / h。后直接比较积极和非侵蚀性的水合作用组,倾向评分匹配进行控制严重,APACHE II和BISAP评分。 Post-match comparison as well as a subgroup comparison were conducted.</p> <p><strong>Results: </strong>At 24 hours, 125 (44.8%) patients received aggressive hydration averaged at 5.1 L (2-18 L), while 154 (55.2%) patients received non-aggressive hydration averaged at 2.5 L. Post-match comparison showed that aggressive hydration group had longer hospital stay (MAP: 5.3 vs 4.5, <em>p</em> = 0.145, MSAP/SAP: 8.3 vs 4.8 d, <em>p</em> = 0.007), and higher rate of intensive care unit admission (mild: 12.9% vs 4.4%, <em>p</em> = 0.042, moderately severe or severe: 36.8% vs 3.1%, <em>p</em> = 0.001), while showed no difference in rate of mortality or re-admission by 1 year. In patients who presented without organ failure, aggressive hydration did not change the rate of development of organ failure (14.1% vs 12.5%, <em>p</em> = 0.731), but the aggressive hydration group had a trend towards longer hospital stay (5.5 vs 4.6 d, <em>p</em> = 0.083) and higher rate of MICU admission (12.1% vs 4.8%,<em> p</em> = 0.051).</p> <p><strong>Conclusion:</strong> Our study did not find mortality or morbidity benefit in patients who received aggressive hydration. The optimal strategy for fluid hydration in AP remains to be elucidated and studies focusing on early non-invasive accurate hemodynamic assessment and fluid resuscitation responsiveness prediction are needed.</p> 11/27/2019//m.lakotalakes.com/hcg/acgh-aid1012.php & lt; h2> Abstract< / h2>& lt; p> & lt; strong>背景:& lt; / strong>This article reviews current knowledge of Gaucher&rsquo;s disease (GD) and liver involvement and reports our experience: how many patients with chronic liver disease of unknown origin could be affected by Gaucher&rsquo;s disease.</p> <p><strong>Patients and methods:</strong> Over 24 months, we tested 75 sine causa chronic liver disease patients (30 women and 45 men, mean age 55 years, range 15 to 77).</p> <p><strong>Results:</strong> None of the 75 patients was affected by Gaucher&rsquo;s disease.</p> <p><strong>Conclusion:</strong> We believe that the chronic liver disease patient is unlikely to be affected by Gaucher&rsquo;s disease. Probably this disease is to be found in cases of coexistence of hepatic disease and other symptoms of Gaucher&rsquo;s disease (bone, neurological, bone marrow involvement).</p> 11/13/2019//m.lakotalakes.com/hcg/acgh-aid1011.php & lt; h2> Summary< / h2><p>Hepatitis C Virus (HCV) infection is usually treated with direct acting antivirals (DAAs) for 12 weeks. In treatment naive patients with genotype (GT) 1 infection without cirrhosis and baseline viral load &lt;6 million, 8 weeks of Ledipasvir/Sofosbuvir (LDV/SOF) is an option. Eight weeks with Glecaprevir/Pibrentasvir (GLE/PIB) is an option for patients with GT 1 through 6 without cirrhosis. Our objective was to evaluate achievement of Sustained Virologic Response (SVR) after 8 weeks of LDV/SOF or GLE/PIB in our HCV-infected veterans. Patients with HCV infection that received GLE/PIB or LDV/SOF for a planned 8 weeks of therapy in the past four years were reviewed (January 2015-September 2018). Treatment outcomes were evaluated through medical record review.</p> <p>Two hundred sixty-five veterans were initiated on 8 weeks of therapy with either GLE/PIB or LDV/SOF. Of these, 231 (87%) were initiated on 8 weeks of LDV/SOF and 34 (13%) were initiated on 8 weeks of GLE/PIB. The majority of patients had GT 1 (93%) infection. One hundred and ninety-five veterans who completed 8 weeks of LDV/SOF and 30 veterans on GLE/PIB had follow-up viral loads. The overall SVR was 95%. Treatment with GLE/PIB resulted in a higher SVR rate (100%) compared to LDV/SOF (95%). Elderly patients had similar SVR rates. Treatment with 8 weeks of DAA is effective in our veteran population and showed an SVR rate similar to literature reports. The SVR for patients treated with 8 weeks LDV/SOF was slightly lower than the SVR for GLE/PIB; however, the GLE/PIB population was smaller.</p> 09/20/2019//m.lakotalakes.com/hcg/acgh-aid1010.php & lt; h2> Summary< / h2>& lt; p> & lt; strong>背景:& lt; / strong>即使目前的标准治疗后血管曲张,包括非选择性b-blockers和重复内窥镜静脉曲张的结扎,再出血的风险和死亡率很高。他汀类药物表现出一个antifibrotic效应和提高HVPG。我们评估是否增加辛伐他汀卡维地洛+ EVL治疗可以减少静脉曲张的rebleeds或死亡在肝硬化患者。;/ p>& lt; p> & lt; strong>方法:& lt; / strong>患者静脉曲张的流血5到10天前被随机分配到组(卡维地洛(n = 69))和B组(卡维地洛(最大剂量- 12.5毫克),和辛伐他汀(40毫克/天)(n = 65)]。主要终点是静脉曲张的出血或死亡。次要终点是新门户的并发症高血压和严重副作用的药物。你们;/ p>& lt; p> & lt; strong>结果:& lt; / strong> During a mean follow-up of 49.05 &plusmn; 25.74 weeks, composite end point i.e. rebleeding or death developed in 23 patients (33.3%) in group A and 12 patients (18.5%) in group B [HR for simvastatin = 0.512; 95% CI: 0.254 &ndash; 1.030; <em>p</em> = 0.06]. In subgroup analysis by excluding patients of Child C class, 18 patients (34.6%) in group A and 7 patients (13.6%) in group B developed composite end point [HR for simvastatin = 0.369; 95% CI: 0.154 &ndash; 0.887; <em>p</em> = 0.026]. 17.4% and 15.4% patients in group A and B developed additional secondary complication [HR = 0.86; 95% CI: 0.345-2.161; <em>p</em> = 0.75). No simvastatin induced significant adverse effects were found.</p> <p><strong>Conclusion:</strong> Addition of simvastatin to carvedilol and EVL may reduce the rebleeding and death in patients with less advance liver disease.</p> <p>&nbsp;</p> 07/08/2019//m.lakotalakes.com/hcg/acgh-aid1009.php & lt; h2> Abstract< / h2><p>Treatments via the minor papilla is effective where the deep cannulation via the major papilla is impossible in such cases as [1] the Wirsung&rsquo;s duct is inflammatory narrowed, bent or obstructed by impacted stones [2] pancreatic duct divisum (complete or incomplete) [3], maljunction of pancreatico-biliary union with stones [4], pancreatic stones in the Santorini&rsquo;s duct. In [1,2] cases, the pancreatic juice flow via the major papilla decreases, while that of the minor papilla increases. Then the size of minor papilla and its orifice shows corresponding enlargement. This substitutional mechanism is an advantage when undertaking our new method. Since the pancreatic juice flow is maintained via the minor papilla in these cases, accurate and careful endoscopic skills are necessary to prevent pancreatitis due to the occlusion of the Santorini&rsquo;s duct after this procedure. We have experienced 135 cases treated via minor papilla in these 27 years, so we would like to report about its safety and efficacy.</p> 06/07/2019//m.lakotalakes.com/hcg/acgh-aid1008.php & lt; h2> Abstract< / h2>& lt; p> & lt; strong>背景:& lt; / strong>Transcatheter arterial embolization can be used for patients with recurrent bleeding from the upper gastrointestinal tract after failed endoscopic treatment. Our aim to identify the clinical and technical factors that influenced the outcome of transcatheter embolization for therapy of upper gastrointestinal bleeding after failed surgery or after failed endoscopic treatment in high risk surgical patients.</p> <p><strong>Methods:</strong> We performed a prospective study to analysis of the 15 patients who underwent Transcatheter arterial embolization for nonvariceal upper gastrointestinal bleeding at Alshifa hospital from January 2015 to March 2019.</p> <p>The following variables were recorded: demographic data, time from bleeding start to TAE, units of packed red cells before TAE and units of packed plasma before Transcatheter arterial embolization and we analysis 30 days rebleeding rates and mortality</p> <p><strong>Results:</strong> Patients treated with Transcatheter arterial embolization (median age: 62 years, range: 14&ndash;79 years).The technical success rate of the embolization procedure was 100%. Time from bleeding start to TAE was 2.1 (1-4) days , units of packed red cells before Transcatheter arterial embolization was 12.8 (4-22) packed and units of packed plasma was 3.2 (2-5) packed. Following 30 days after embolization, 2 (13%) patients had repeated bleeding and 3 (20.0%) patients died.</p> <p><strong>Conclusion:</strong> In our experience, arterial embolization is a safe and effective treatment method for upper gastrointestinal bleeding and a possible alternative to surgery for high-risk patients.</p> 04/26/2019//m.lakotalakes.com/hcg/acgh-aid1007.php & lt; h2> Summary< / h2><p>Pseudomyxoma peritonei or Gelatinous Peritoneal Disease is a rare disease. We report a case treated in the department of Hepato-Gastroenterology at Ibn Sina Hospital in Rabat, of a 64-year-old male who presented with an abdominal pain and an increased volume of the abdomen corresponding to ascites. Imaging and anatomopathological study made it possible to diagnose the disease. However, given the general state of the patient, he is under palliative care.</p> 07/11/2018//m.lakotalakes.com/hcg/acgh-aid1006.php & lt; h2> Abstract< / h2><p>43-year-old lady presented with incidentally discovered liver lesions while she was being managed for her complaints of menorrhagia. CT and MRI showed hepatomegaly with multiple lesions in both lobes of the liver with vascular element in the background of diffuse fatty infiltration. Patient underwent laparoscopic core biopsy. Histopathology showed extensive steatosis, intracytoplasmic giant mitochondria and absence of portal tracts, features highly suggestive of hepatic adenomatosis. IHC staining showed membranous and cytoplasmic positivity in hepatocytes for B-catenin consistent with multiple hepatic adenomatosis. Hepatic adenomatosis is a new clinical entity in the hepatological practice characterized by the presence of 10 or more nodules in the liver known for its major complication of bleeding. Hepatic adenomatosis is managed by regular imaging and resection of large (&gt; 5cm) superficial and painful adenomas along with liver function tests and tumor markers to rule out malignant transformation. However, the potential cure being the liver transplantation.</p> 01/19/2018//m.lakotalakes.com/hcg/acgh-aid1005.php & lt; h2> Abstract< / h2>& lt; p> & lt; strong>背景:& lt; / strong>Pyogenic liver abscesses (PLA) are frequent in immunosuppressed patients. We review the characteristics of patients with PLA at a tertiary academic Spanish hospital in Asturias.</p> <p><strong>Methods:</strong> A retrospective observational study for 10 years, between 2006-2015. Epidemiological, clinical, analytical characteristics, treatment and hospital stay of the patients with PLA were analyzed.</p> <p><strong>Results:</strong> 99 patients, 62 (62.6%) men, with age &ge;65 years (72.7%). The most frequent etiology was: Biliary (40%), postsurgical (15%) and intestinal origin (11%). The most frequent clinical signs were fever, showing significant differences, abdominal pain (p=0.001) and nausea (p=0.02) between biliary PLA and the rest of the PLA. Microbiological results were confirmed in 63% (62 cases). All were treated with antibiotic therapy, along with percutaneous drainage (44.4% (44 cases)); and surgical drainage (12.1% (12 cases)). The overall mean stay was 23.1 days without significant differences between those treated with percutaneous drainage or surgical drainage.</p> <p><strong>Conclusion:</strong> PLA predominate in patients &ge;65 years. Biliary PLA are the most frequent, diagnosed at an older age than the intestinal PLA (p=0.005).<br /> <br /> - The treatment is based on systemic antibiotherapy and percutaneous drainage, especially in PLA only &gt;5cm (p=0.019).<br /> <br /> - There are no significant differences in average stay of patients treated with percutaneous drainage or surgical drainage.</p> 12/29/2017//m.lakotalakes.com/hcg/acgh-aid1004.php & lt; h2> Abstract< / h2>& lt; p> & lt; strong>目的:& lt; / strong>这项研究的目的是访问的流行配饰对劣质在肝移植肝静脉及其相关意义。;/ p>& lt; p> & lt; strong>材料与方法:& lt; / strong>一个回顾性研究了82年的CT潜在的肝脏移植候选人综述了2012年1月至2013年3月。副右肝静脉低劣的检查;辅助下肝静脉的直径和它们之间的距离开放到下腔静脉在冠状面和向右肝vein-inferior腔静脉连接测量。;/ p>& lt; p> & lt; strong>结果:& lt; / strong>的82个患者中,42例(51%)有附属权利下肝静脉。正确的附件下肝静脉大于3毫米23名(28%)病人中被检测到。 The distance of these veins to the right hepatic vein-inferior vena cava junction was more than 4 cm in 13 (15%) patients.</p> <p><strong>Conclusion:</strong> The precise preoperative knowledge of accessory right inferior hepatic veins is essential in living donor liver transplantation.</p> 08/25/2017//m.lakotalakes.com/hcg/acgh-aid1003.php & lt; h2> Abstract< / h2><p><strong>Aim:</strong> To identify the possibility of correction of motor function of the gastro-intestinal tract in experimental pancreatitis with the administration of infliximab.</p> <p><strong>Material and methods:</strong> Pancreatitis was modeled by the administration of picrylsulfonic acid retrogradely into the pancreatic duct of rat (n=5) and 4 animals were control. Electromyogram (EMG) of the pancreatic duct was monitored immediately after the administration of picrylsulfonic acid and on the 15th day of pancreatitis simulation before and after the administration of infliximab. The morphological investigation of pancreas was conducted on the 15th day of development of pancreatitis and on the 15th day of treatment of pancreatitis with infliximab.</p> <p><strong>Results:</strong> Infliximab restores the motor function of pancreatic duct and structure of pancreas during acute pancreatitis.</p> <p><strong>Conclusion:</strong> Protective action of infliximab during acute pancreatitis was shown.</p> 07/14/2017//m.lakotalakes.com/hcg/acgh-aid1002.php <h2>ABSTACT</h2> <p>Anemia due to gastrointestinal blood loss can occur due to many conditions and rarely to bowel structural anomalies. We report a 12 years old girl with anemia due to small bowel duplication cyst, posing diagnostic challenge intra operatively. Surgery offered cure without recurrence of bleeding. Common symptoms can be due to a rare surgical condition in practice.</p> 07/10/2017//m.lakotalakes.com/hcg/acgh-aid1001.php <h2>ABSTRACT</h2> <p>Obstructive jaundice in children is not uncommon and has diverse etiologies. We report a rare cause of obstructive jaundice, cholangitis and pancreatic mass in a young boy due to eosinophilic cholangiopathy who responded to oral steroids. Presence of peripheral eosinophilia, elevated serum IgE level, radiological imaging and tissue eosinophilia helped in diagnosis. Eosinophilic cholangiopathy with pancreatitis is a benign treatable cause of obstructive jaundice though it can masquerade as malignancy.</p>