2021 - 11 - 22 - t15:20:50z //m.lakotalakes.com/oai/oai.php

的oai: heighpubs.org: 10.29328 / journal.jccm.1001104 2020-10-02 JCCM: VOL5

抗生素诱导线粒体发生变化，可能导致致癌、心脏病理、其他医疗条件和生态系统风险 约玛•Jyrkkanen & lt; h2> Abstract< / h2>Calghatgi(2013)发现三种常见抗生素(Abs)会增加线粒体活性氧(ROS)和脂质过氧化物(LP)，并耗尽它们的天然吸水性谷胱甘肽，这让我进一步研究了这些基因毒性物质对致癌的潜在影响。抗生素对线粒体和细胞DNA的影响范围因抗生素不同而不同，这些影响与先前已知的致癌作用一致。这些改变可能会增加一些特定的癌症，如HCC, RCC (KCC)， CRC，食道癌。LP导致的抑癌基因突变值得注意，CRC中诱导的突变与CRC癌变中发现的突变一致。此外，短链脂肪酸在微生物组中被发现抑制免疫系统，增加所有癌症的风险。根据流行病学研究，许多癌症增加了，Abs与升高的优势比有关，其中一个特别令人担忧的是致命乳腺癌。线粒体功能丧失的影响还与柠檬酸循环的抑制有关，因此ATP使代谢转向糖酵解，Warburg机制也增加了所有癌症的风险，这是癌细胞的偏好。综上所述，许多癌症类型的某些部分的可能性可能会因Abs治疗的数量、类型和频率以及慢性残留暴露的不同而有所增加。这让我提出了Abs. 1的三种致癌机制。 Cancer critical mutations 2. Immune depression 3. loss of mitochondrial functionality leading to Warburg effects. Damage to mitochondria were also noted by common pesticides tested in China and cancer associations were also found for many pesticides supporting a similar contributory etiology. Heart health concerns were raised by these findings because of the myriad mitochondria in the heart and because of long term reliability needs. Studies suggesting hearts were affected by Abs and pesticide exposure were presented. Because of their geographical ubiquitousness and the huge range of diseases associated with mitochondrial dysfunction, antibiotics and pesticides and bacteriocidal biocides are of concern for biodiversity and life in general. I propose research steps to evaluate Abs safety and suggest directions for further research and make suggestions on ways to ameliorate Abs toxicity.</p> 心脏病学和心血管医学杂志-提高科学出版公司188bet体育 2020-10-02 研究文章 //m.lakotalakes.com/jccm/jccm-aid1104.php 在 版权所有©Jorma Jyrkkanen